In this paper, an optimization technique for thin walled beams of vehicle body structure is proposed. Stiffness of thin walled beam structure is characterized by the thickness and typical section shape of the beam structure. Approximate functions for the section properties such as area, area moment of inertia, and torsional constant are derived by using the response surface method. The approximate functions can be used for the optimal design of the vehicle body that consists of complicated thin walled beams. A passenger car body structure is optimized to demonstrate the proposed technique.