- 흰쥐에서 사염화 탄소로 유도된 간독성에 미치는 더위지기 추출물의 영향-II. 더위지기 추출물의 투여용량이 사염화 탄소 독성에 미치는 효과
- ㆍ 저자명
- 권진욱,이규승
- ㆍ 간행물명
- 환경독성학회지
- ㆍ 권/호정보
- 2002년|17권 2호|pp.175-185 (11 pages)
- ㆍ 발행정보
- 한국환경독성학회
- ㆍ 파일정보
- 정기간행물| PDF텍스트
- ㆍ 주제분야
- 기타
To investigate effects of A. gmelini on the 14-day CCl$_4$induced hepatotoxicity, extracts were prepared in 3 ml saline at the dose of 50, 500, 5,000 mg/kg b.w. to administer orally everyday and same concentration (1 : 9, CCl$_4$: olive oil v/v) of CCl$_4$administered intraperitoneally with 2.5 ml/kg b.w. On the 7th day, hemanalysis showed following recovery values; AST 9.9∼64.6%, ALT 36.9∼71.9%, ALP 75.3∼93.7%, BUN 53.8∼59.7%, TBIL 60.4∼100.0< %, TCHO 77.7∼100.0< %, and TG 60.4∼100.0< %. Even if, 14-day CCl$_4$induced hepatotoxicity recovery was found to depend on doses of extract, and recovery values of each treatment were AST 13.8∼56.4%, ALT 15.7∼68.0%, ALP 53.4∼84.4%, BUN 76.9∼100.0< %, TBIL 60.4 ∼ 100.0< %, TCHO 82.6∼99.3< %, and TG 56.7∼99.7%. By histological examination of liver, hydropic degeneration, fatty change, lipid accumulation and necrosis were also recovered.