- In vitro 실험법에 의한 천연물 중의 UVA 광독성 억제제 검색
- ㆍ 저자명
- 김현진,김봉희
- ㆍ 간행물명
- 환경독성학회지
- ㆍ 권/호정보
- 2002년|17권 3호|pp.253-259 (7 pages)
- ㆍ 발행정보
- 한국환경독성학회
- ㆍ 파일정보
- 정기간행물| PDF텍스트
- ㆍ 주제분야
- 기타
The phototoxicity inhibitory activity of 15 natural products having antiinflammatory effect was screened by three in vitro methods: yeast growth inhibition test with Candida albicans, RBC photohemolysis and MTT assay. We induced phototoxic reaction by irradiating UVA (365 nm) on chlorpromazine (CPZ) that has been widely documented as phototoxic agent in clinical and experimental studies and then observed the effects of the natural products after treating them with CPZ. In yeast growth inhibition test, X. stramonium showed the inhibitory effect on the UVA phototoxicity and E. officinalis, Yeast, P. suffruticosa showed phototoxicity inhibitory effect in that their % hemolysis compared with control were 36.14${pm}$ 2.69, 42.82${pm}$1.35, 36.41${pm}$0.48 on UVA. In MTT assay, all tested natural products increased cell viability compared with the control.