We compared the hypoglycemic effects of Ginseng Radix Alba (GRA) and Mori Folium (MF) in multiple low dose (MLD) streptozotocin(STZ)-induced diabetic rats. In order to induce hyperglycemic state 25 mg/kg of STZ was injected intraperitoneally for 5 consecutive days. SD rats were randomly divided into diabetic control and treatment groups. Treatment groups were administered with either 500 mg/kg of GRA (G500), 500 mg/kg of MF (M500), or 250 mg/kg of GRA mixed with same dose of MF (GM250) for 3 weeks. Blood glucose level and body weight were measured every 5th day. G500 and M500 both significantly reduced blood glucose levels as compared to the diabetic control group (diabetic control, 458.3$pm$25.4 mg/dl; G500, 275.0$pm$12.0; M500, 278.0$pm$15.4; GM250, 324.0$pm$18.4). While body weight in diabetic control group was decreased slightly after 3 weeks, treatment groups showed gradual increases of body weight during 3 week-period. Plasma insulin level was increased by treatment with GRA, but those levels in M500 and GM250 groups were similar to the diabetic control (normal control, 32.0$pm$13.9 $mu$IU/mι; diabetic control, 12.4$pm$1.9; G500, 17.5$pm$3.4; M500, 11.1$pm$3.2; GM250, 10.5$pm$t3.7). Urine glucose levels were also remarkably reduced in all treatment groups (normal control, 0.0$pm$0.0 g/day; diabetic control, 11.4$pm$2.5; G500, 4.9$pm$0.2; M500, 5.7$pm$1.6 ; GM250, 8.2$pm$0.2). At the second and third week of the treatment, food and water intakes were determined. At the third week, food and water intakes were significantly decreased in all treatment groups. Taken together, we may conclude that GRA and MF alone may prevent or delay the development of hyperglycemia, however, synergistic hypoglycemic activity was not be seen in group treated with mixed formula of GRA and MF when compared to GRA or MF alone.