Of srategic importance nowdays is the development of high performance spacecraft bus. In this study, optimization for spacecraft structure is performed under the framework of coupled load analysis which is a branch of component mode synthesis with constrained mode and modal transient analysis. unlike the traditional method which uses the quasi-static table supplied by launch vehicle contractor, the present method adots the load results of previous coupled load analysis. It if shown that the proposed method can serve as a effective tool for the optimization spacecraft structure in the early stage of design and weight reduction by numerical example.