The hydrogen gas pick-up problem that can occur during Lost Foam Casting was investigated by reduced pressure test and practical Lost Foam Casting. The proper test pressure of reduced pressure test was determined by experiments not to use polystyrene and gas contents of the melt were calculated from density measurement results. The results showed that the hydrogen pick-up increased with the increased amount of polystyrene that was replaced by melt. The hydrogen pick-up was larger in the case of no degassed melt than that of degassed melt. So the hydrogen pick-up depended on the initial hydrogen content of the melt and the contact time of the melt with the decomposed gas phase. The mold evacuation decreased the hydrogen pick-up and increased the flow length of melt during Lost Foam Casting. And the error of calculated hydrogen pick-up was calculated by numerical method.