The purposes of this research were to: a) define the changing trends of DRGs in comparison to the National Data, b) define the changing trends of Nursing Diagnoses and Nursing Interventions for the 5 most frequently occurring Diagnostic Related Groups (DRGs) across 3 years, and c) define the relationships between nursing diagnoses and nursing Interventions for the 5 most frequently occurring DRGs across the 3 years. This study was a secondary data analysis of medical and nursing data based on the United States Nursing Minimum Data Set and the Uniform Hospital Discharge Data Set retrieved from a Midwestern USA medical center. The results showed interesting comparisons with national statistics as well as practice relevant trends within the nursing data. Additionally, the results showed the possibility that nursing data can be extracted from the medical data, so they can used in the nursing productivity and cost issues etc. In conclusion, this study supports the power of minimum data sets and nursing classifications to begin to describe a more global perspective the inter-relationships and trends of nursing data within the medical diagnosis context.