In this paper, structure design of the payload section of the KSR-III was performed. The payload section of the KSR-III, which corresponds to the second stage, consists of the Scientific Payload Section for the mission of the rocket, the Payload Section (Electronics) for the communication between the rocket and the ground station, and the Payload Section (Attitude Control) for the attitude control of the rocket. In order to accomplish the mission, every payload and component should operate successfully during the mission period and the structure must satisfy the requirements of the payloads. In this research, precise composition of the payload section and payloads arrangement of the KSR-III were performed. And the modification of the structure to meet the requirements were described.