Physicochemical changes of poloxamer-based gel containing capsaicin analog (N-[3-(3,4-dimethylphenyl)propyl]-4-(2-aminoethoxy)-3-methoxyphenyl acetamide) such as drug content, viscosity and surface tension were investigated during the storage conditions at three different temperatures (25, 40 and $60^{circ}C$) over 90 days. No noticeable changes of color were observed when stored at 25 and $40^{circ}C$. However, the color of white poloxamer gels turned yellow during storage at $60^{circ}C$. The drug contents were unchanged during storage at $25^{circ}C$ but had tendency to decrease at $40^{circ}C$. The drug contents were highly decreased over 40-50% when stored at $60^{circ}C$. The viscosity of a poloxamer-based gel was unchanged during storage at 25 and $40^{circ}C$ but greatly increased at $60^{circ}C$. The surface tension of a poloxamer-based gel was not changed at three different temperatures. The storage conditions of a poloxamer-based gel containing capsaicin analog can be considered for further clinical applications.