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심바스타틴 자가유화약물전달시스템의 마이크로캡슐화를 통한 고형제제의 개발
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  • 심바스타틴 자가유화약물전달시스템의 마이크로캡슐화를 통한 고형제제의 개발
저자명
강복기,윤복영,서광수,정상영,길희주,강길선,이해방,조선행,Kang. Bok-Ki,Yoon. Bok-Young,Seo. Kwang-Su,Jeung. Sang-Young,Kil. Hee-Joo,Khang. Gil-Son,Lee. Ha
간행물명
藥劑學會誌
권/호정보
2003년|33권 2호|pp.121-127 (7 pages)
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한국약제학회
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정기간행물|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

The objective of this study was to solidify the simvastatin self-microemulsifying drug delivery system (SMEDDS) and to improve the encapsulation efficiency of solidified alginate beads using sodium alginate. Typical simvastatin SMEDDS was composed of various oils, surfactants and cosurfactants. Also solidified-alginate beads was prepared by crosslinking liquid emulsion mixtures containing sodium alginate and other excipients (cetylpyridinum chloride (CP-Cl), hydroxypropyl methylcellulose, starch and so on). in $CaCl_2$ solution, it has been investigated that the drug release pattern and encapsulation efficiency were varied with the ratio of cationic lipid (CP-Cl). Solidified sodium alginate beads containing simvastatin SMEDDS were redispersed into media without re-aggregation. Oil droplet size of redispersed solidified-beads in media produced smaller than the initial size. The density of beads and drug loading amount were increased with increasing cationic lipid content. These systems have advantages of storage stability and predictability of drug release rate.