Numerical studies have been conducted to predict the solid-liquid separation efficiency of turbulent flow in a hydrocyclone using a commercial CFD code. To validate the CFD code, several preliminary numerical calculations are carried out to determine the influence of parameters such as grid systems, numerical schemes, and turbulence models. The numerical studies have been performed on the hydrocyclones with the different vortex finder geometries by changing the mass flow rate, and the results were compared with the experimental data. The results show that the CFD code can be used as a design tool to improve the performance of hydrocyclones.