As the size of a combustor decreases to a MEMS scale, heat loss increases and becomes a dominant effect on the performance of the devices. Existing models, however, are not adequate to predict the heat transfer and combustion processes in such small scales. In the present study, a semi-empirical model to calculate heat loss from a micro combustor is described. The model derives heat transfer coefficients that best fits the heat loss characteristics of a micro combustor that is represented by transient pressure record after combustion is completed. From conservation of energy equation applied to the burned gas inside the combustor, a relationship between pressure and heat transfer is reduced. Two models for heat transfer coefficients were tested; a constant and first order polynomial of temperature with its coefficients determined from fitting with measurements. The model was tested on a problem of cooling process of burnt gas in a micro combustor and comparison with measurements showed good agreements. The heat transfer coefficients were used for combustion calculation in a micro vessel. The results showed the dependence of flame speed on the scale of the chamber through enhanced heat loss.