A new algorithm based on Genetic Algorithms is proposed f3r solving process optimization problems formulated in MINLP, GDP and hybrid MINLP/GDP. This work is focused especially on the design of the Genetic Algorithm suitable to handle disjunctive programming with the same level of MINLP handling capability. Hybridization with the Simulated Annealing is experimented and many heuristics are adopted. Real and binary coded Genetic Algorithm initiates the global search in the entire search space and at every stage Simulated Annealing makes the candidates to climb up the local hills. Multi-Niche Crowding method is adopted as the multimodal function optimization technique. and the adaptation of probabilistic parameters and dynamic penalty systems are also implemented. New strategies to take the logical variables and constraints into consideration are proposed, as well. Various test problems selected from many fields of process systems engineering are tried and satisfactory results are obtained.