Optical Switching Matrix (OSM) or Optical Multistage Interconnection Networks (OMINs) comprising photonic switches have been studied extensively as important interconnecting blocks for Optical Cross Connects (OXC) based on Optical Burst Switching (OBS). A basic element of photonic switching networks is a 2$ imes$2 directional coupler with two inputs and two outputs. This paper is concerned with the diagnosis of multiple crosstalk-faults in OSM. As the network size becomes larger in these days, the conventional diagnosis methods based on tests and simulation become inefficient, or even more impractical. We propose a simple and easily implementable algorithm for detection and isolation of the multiple crosstalk-faults in OSM. Specifically. we develop an algorithm for isolation of the source fault in switching elements whenever the multiple crosstalk-faults arc detected in OSM. The proposed algorithm is illustrated by an example of 16$ imes$16 OSM.