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Strawberry, Garlic and Kale Consumption Increase Urinary Excretion of Dimethylamine and Trimethylamine in Humans
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  • Strawberry, Garlic and Kale Consumption Increase Urinary Excretion of Dimethylamine and Trimethylamine in Humans
  • Strawberry, Garlic and Kale Consumption Increase Urinary Excretion of Dimethylamine and Trimethylamine in Humans
저자명
Chung. Mi-Ja,Lee. Soo-Jung,Shin. Jung-Hye,Sung. Nak-Ju
간행물명
Nutraceuticals and food
권/호정보
2003년|8권 1호|pp.19-23 (5 pages)
발행정보
한국식품영양과학회
파일정보
정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

Dimethylamine (DMA) is the immediate precursor of carcinogenic N-nitrosodimethylamine (NDMA). In vitro and in vivo experiments using whole strawberries, and garlic and kale juices were conducted to determine concentrations of DMA and trimethylamine (TMA) in foods and urine. Experimental diets [an amino-rich diet as nitrosatable precursors in combination with added nitrate-containing drinking water without (TD1) or with whole strawberries or garlic or kale juices (TD2, TD3 and TD4, respectively), or a diet of low in nitrate and amino (TD5) were incubated in simulated saliva and gastric juices at 37$^{circ}C$ for 1 hour. We also studied the urinary excretion of DMA and TMA after consumption of the experimental diets (TD1~TD5). Urine samples were obtained for 18 hrs after consumption of experimental diets and concentrations of DMA and TMA were measured in the digested diet and urine. The DMA concentration after incubation in experimental diets (TD1~TD5) was 4.7$pm$0.3, 6.7 $pm$0.2, 7.9$pm$0.2, 7.1$pm$0.2 and 0.3$pm$0.1 mg/kg, respectively. Urinary excretion of DMA (TD1~TD5) was 22.0$pm$5.0, 28.3$pm$4.3, 29.2$pm$4.1, 27.4$pm$4.5 and 20.4$pm$3.1 mg/18 hr, respectively. Consumption diets with added strawberries or juices of kale or garlic increased urinary TMA and DMA, suggesting that those precursors were excreted and not converted to the carcinogen, NMDA.