A FEM-based analytical approach was used to evaluate the multiaxial high cycle fatigue damage of an automotive sub-frame. Elastic Multi Body Simulation (MBS) has been applied in order to determine the multiaxial load histories. The stresses due to these loads have been given by FE computation. These results have been used as the input for the multiaxial fatigue analysis. For the assessment of multiaxial high cycle fatigue damage, the signed von Mises, the signed Tresca, the absolute maximum principal stress and critical plane methods have been employed. In addition, the biaxiality ratio, a$sub$e/, the absolute maximum principal stress, $sigma$$sub$p/ and the angle, $phi$$sub$P/, between $sigma$$sub$1/ and the local x-axis, have been calculated to evaluate the stress state at each node.