MDO (multidisciplinary design optimization) technology has been proposed and applied to solve large and complex optimization problems where multiple disciplinaries are involved. In this research. an MDO problem is defined for automobile design which has crashworthiness analyses. Crash model which are consisted of airbag, belt integrated seat (BIS), energy absorbing steering system .and safety belt is selected as a practical example for MDO application to vehicle system. Through disciplinary analysis, vehicle system is decomposed into structure subspace and occupant subspace, and coupling variables are identified. Before subspace optimization, values of coupling variables at given design point must be determined with system analysis. The system analysis in MDO is very important in that the coupling between disciplines can be temporary disconnected through the system analysis. As a result of system analysis, subspace optimizations are independently conducted. However, in vehicle crash, system analysis methods such as Newton method and fixed-point iteration can not be applied to one. Therefore, new system analysis algorithm is developed to apply to crashworthiness. It is conducted for system analysis to determine values of coupling variables. MDO algorithm which is applied to vehicle crash is MDOIS (Multidisciplinary Design Optimization Based on Independent Subspaces). Then, structure and occupant subspaces are independently optimized by using MDOIS.