Twenty eight new species of Acentropinae are described from the Philippines: Nymphieula negrosensis sp. nov., N. mindorensis sp. nov., N. zambalensis sp. nov., N. samarensis sp. nov., N. banauensis sp. nov., Eoophyla pulehralis sp. nov., E. naumanni sp. nov., E. fontis sp. nov., E. nussi sp. nov., E. riehteri sp. nov., E. yeni sp. nov., E. quezonensis sp. nov., E. bieolensis sp. nov., E. litoralis sp. nov., E. montanalis sp. nov., E. eallilithalis sp. nov., E. sehintlmeisteri sp. nov., E. ley tens is sp. nov., E. eernyi sp. nov., E. napoleoni sp. nov., E. eervinalis sp. nov., Eristena samaritai sp. nov., Margarostieha nigreseens sp. nov., Paraeymorizafuliginosa sp. nov., P. argenteolineata sp. nov., P. nigrella sp. nov., Parapoynx leueographa sp. nov., and P. pyenarmonides sp. novo New generic combinations: Ambia triehostylalis Hampson, 1897 from Sulawesi is transferred from the Musotiminae to Eoophyla (Acentropinae) where it stands as Eoophyla triehostylalis (Hampson, 1897) comb. n.; Eoophyla wollastoni (Rothschild, 1915) comb. n. (Aulaeodes), Eoophyla flavifaseialis (Hampson, 1917) comb. n. (Aulaeodes), Eoophyla longiplagialis (Hampson, 1917) comb. n. (Aulaeodes), the last three species are from Irian Jaya; and Eoophyla stresemanni (Rothschild, 1915) (Aulaeodes) comb. n. from Ceram. The male and female genitalia are illustrated together with pictures of the adults. The diagnostic features of the species are given and the nearest relatives are indicated. All new species are Philippine endemics. The rate of endemism in the Acentropinae of the Philippines is about 85%. This remarkable high percentage, corroborating the notion that the Philippines are a hot spot of biodiversity in South East Asia, points to the particular geographic situation and geological history of the Philippine Islands.