The sensitivity analysis of a middle wave infrared optical system with 20: 1 zoom ratio is performed to analyze manufacturing and alignment tolerances, and to establish the alignment logic and the focus control strategy. The characteristics of the sensitivities of Zernike coefficients are investigated to all mechanical displacements and several zoom positions using Code-V Macro. From this result, the tolerances of manufacturing and alignment of the optical system are derived and the effective alignment logic is established. Futhermore, an effective focus control strategy is established to make the system simple and compact.