A study of the performance effect of Indolene-Methanol Plus High Alcolhols (MPHA) has been completed. The study invested the measurement of performance parameters. The performance parameters measured are minimum advance for best torque (MBT) spark timing, power output and thermal efficiency. The alcohol concentration was varied from 0 to 100 percent by volume in clear Indolene. The performance parameters were measured using a single cylinder spark ignition engine at different compression ratios. The results of the performance measurements indicated that Indolene-MPHA blends have a higher MBT spark advance, similar power output and lower thermal efficiencies than Indolene-Methanol blends.