In Gravure printing process, there are a lot of printing errors caused by expansion and contraction of printing materials and difficulty of printing of small letters, accordingly we cannot detect those errors with eyes. In this paper, we describe the algorithm which can detect small errors automatically in Gravure printing process and a real-time detection system adopting the algorithm. We present the Perimetric Mask algorithm that can eliminate tiny errors occurring near the contour of printing objects to achieve accurate inspection, and also construct an algorithm utilizing symmetry transform which can emphasize tiny errors to make a robust inspection system. We have made a system running in real-time and verified the efficiency of the algorithm.