Five two-phase closed loop thermosyphons (TLTs) specially designed and constructed for the present study are one small scale loop, two medium scale loops (MSLI and MSLII) and two large scale loops (LSLI and LSLII). Two simulation models based on thermal resistance network, lumped and sectorial, are presented. In the Lumped model, the evaporator section is dealt as one lumped boiling section. Whereas, in the Sectorial model, all possible phenomena which would occur in the evaporator section due to the two-phase boiling process are considered in detail. Flow regimes, the flow transitions between flow regimes and other two-phase parameters involved in two-phase flows are carefully analyzed. In the present study, the results of two different simulation models are compared with experimental results. The comparisons showed that the simulation results by the Lumped model and by the Sectorial model did not show any partiality for the model used for the simulation. The simulation results according to the correlations show the various results in the large different range.