Controlled Release of Epidermal Growth Factor (EGF) from EGF-loaded Polymeric Nanoparticles Composed of Polystyrene as Core and Poly(methacrylic acid) as Corona in vitro

Controlled Release of Epidermal Growth Factor (EGF) from EGF-loaded Polymeric Nanoparticles Composed of Polystyrene as Core and Poly(methacrylic acid) as Corona in vitro
Controlled Release of Epidermal Growth Factor (EGF) from EGF-loaded Polymeric Nanoparticles Composed of Polystyrene as Core and Poly(methacrylic acid) as Corona in vitro

ㆍ 저자명: Park. In-Kyu,Seo. Seog-Jin,Akashi. Mitsuru,Akaike. Toshihiro,Cho. Chong-Su
ㆍ 간행물명: Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
ㆍ 권/호정보: 2003년|26권 8호|pp.649-652 (4 pages)
ㆍ 발행정보: 대한약학회
ㆍ 파일정보: 정기간행물|ENG|
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ㆍ 주제분야: 기타

이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.

서지반출

기타언어초록

Polymeric nanoparticles composed of polystyrene (PS) as core and poly(methacrylic acid) (PMA) as corona were prepared by the dispersion copolymerization. The potential of the nanoparticles as carriers for recombinant human epidermal growth factor (EGF) was investigated. The nanoparticles showed monodispersity and good water-dispersibility. The loading content of EGF to the nanoparticles was very high due to electrostatic interaction between EGF and nanoparticles. EGF was released as a pseudo-zero order pattern after initial burst effect. The nanoparticles were sufficient for A431 cells proliferation.

키워드

Polymeric nanoparticles Recombinant human epidermal growth factor A431 cells Cell proliferation

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