In this paper we tried to classify the pathological voice signal with severe noise component based on two different parameters, the spectral slope and the ratio of energies in the harmonic and noise components (HNR), The spectral slope is obtained by using a curve fitting method and the HNR is computed in cepstrum quefrency domain. Speech data from normal peoples and patients are collected, diagnosed and divided into three different classes (normal, relatively less noisy and severely noisy data), The mean values and the standard deviations of the spectral slope and the HNR are computed and compared with in the three kinds of data to characterize and classify the severely noisy pathological voice signals from others.