Purpose: this study was to identify influencing factors of burnout on oncology nurses. Method: the data was collected using a questionnaire from October 18, 2002 to November 20, 2002 in five general hospitals at Seoul. Participants of this study were the nurses who worked in the wards occupied by more than 50 percent of cancer patients. The collected data were analyzed by using the SPSS10.0 program. Result: 1. The burnout of the subjects show a mean score of 2.72 using the 5 point Likert scale. There were statistically significant difference in burnout between the general characteristics; age, marital status, educational background, job experience, position, nursing service period, and attitudes on nursing job. 2 The self-esteem of the subjects show a mean score of 3.72 using the 5 point Likert scale. The spiritual well-being of the subjects show a mean score of 3.83 using the 6 point Likert scale. The social support of the subjects show a mean score of 3.74 using the 5 point Likert scale. The job stress of the subjects show a mean score of 2.16 using the 4 point Likert scale. 3. The result of correlation between burnout and other variable was that relationship between the burnout and job stress(r=-.206, p<.05), self-esteem(r=-.417, p<.01), spiritual well-being(r=-.403, p<.01), social support(r=-.386, p<.01) were significant variables. 4. The result of the Stepwise Multiple Regression was that self-esteem (17.4%), spiritual well-being(7.9%), social support(3.4%) and job stress(2.3%) explained 31% of burn out.