Purpose: To investigate the effects of self-management course in patients with ankylosing spondylitis. Method: Forty-nine subjects were sampled according to research criteria, and divided into two groups: 24 of the experimental group and 25 of control group. To the experimental group, self-management course which developed by the investigators was applied for 6 weeks, each session adopted for two hours per week and additional 30-minutes exercise was carried out two times a week. Result: After participating the self-management course in experimental group, 1) the degree of pain was significantly decreased 2) significant improvement in the flexibility of lumbar spine, 3) uncertainty was significantly decreased. 4) Self-efficacy was not changed between the two groups after self-management course. Conclusions: These findings indicate that the self-management course could be effective in improving the flexibility of lumbar spine and decreasing pain, and uncertainty in patients with ankylosing spondylitis.