The biodeterioration on Iksan Mireuksaji pagoda has been studied with fucus on application of K201 as a chemical treatment. Total of 39species, including 10 algae, 16 lichens, 6 mosses and 7 unidentified bacteria and fungi, were collected and identified on the surface of the pagoda. Most of them caused serious discoloration on the surface. The effectiveness and stability of K201 was examined by applying it on some part of the pagoda. A mild spraying of solution diluted to half of original reagent was good enough to eliminate all the deteriorating species on the surface. Most of discoloration disappeared after the treatment except the red color caused by iron substance. The effectiveness of the regent was compared with water wash. The stone was first washed with water and the dirt on the surface was scrubbed off from the surface. The initial surface of the stone was clearer in water wash. However, many of the deteriorating species reappear in 4 weeks after water wash. Although spraying of the reagent K201 could noteliminate all the remnant of dead organisms as good as scrubbing the surface, no deteriorating algae or lichen was observed until two month after treatment. Therefore, spraying method with chemicals seems more stable and reliable way to remove the biodeterioration than physical scrubbing of the surface.