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Synthesis of [18F]Fluorocholine Analogues as a Potential Imaging Agent for PET Studies
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  • Synthesis of [18F]Fluorocholine Analogues as a Potential Imaging Agent for PET Studies
  • Synthesis of [18F]Fluorocholine Analogues as a Potential Imaging Agent for PET Studies
저자명
Yu. Kook-Hyun,Park. Jeong-Hoon,Yang. Seung-Dae
간행물명
Bulletin of the Korean Chemical Society
권/호정보
2004년|25권 4호|pp.506-510 (5 pages)
발행정보
대한화학회
파일정보
정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
서지반출

기타언어초록

There have been intensive studies concerning $[^{11}F]$choline ($[^{11}F]$methyldimethyl( ${eta}$ -hydroxyethyl) ammonium) (1) which is known as a very effective tracer in imaging various human tumors localized in brain, lung, esophagus, rectum, prostate and urinary bladder using Positron Emission Tomography (PET) and there is increasing interest in $^{18}F$ labelled choline (2) and proved to be useful to visualize prostate cancer. We have prepared six $^{18}F$ labelled alkyl choline derivatives (3a-3c, 4a-4c) from ditosylated and dibrominated alkanes in moderate yields. The six alkyl tosylate or bromate ammonium salts have been synthesized as precursors. Radiofluorination was achieved by the treatment of precursors with $^{18}F$ - in the presence of Kryptofix-2.2.2.. The labeling yields varied ranging from 7 to 25%.