This study aims to derive the operation method of a comprehensive ventilation system which is capable of providing passengers with safe exit paths from platforms in onboard fire situations. To accomplish this, the airflow distributions in subway platforms under 6 types of tunnel vent system were calculated in addition to having analyzed diffusion behaviors of smoke and heat exhaust in such states by performing 6 kinds of different ventilation scenarios in a 3-D Fire Dynamic Simulation (FDS) simulation model. In order to recommend the mechanical smoke exhaust operation mode, Subway Environmental Simulation(SES) is used to predict the airflow of the inlet and outlet tunnel for the subway station to clarify the safety evaluation fir the heat and smoke exhaust on subway fire events.