An experimental study on the refrigerant-side pressure drop of slit fin-tube heat exchanger has been carried out. A comparison was made between the predictions of previously proposed empirical correlations and experimental data for the pressure drop on design conditions of condenser in micro-fin tube for R22 and its alternatives, R407C (R32/125/134a, 23/25/52 wt.％) and R410A (R32/125, 50/50 wt.％). Experiments were carried out under the conditions of inlet refrigerant temperature of 6$0^{circ}C$ and mass fluxes varying from 150 to 250 kg/$m^2$s for R22, R407C and R410A. The inlet air conditions are dry bulb temperature of 35$^{circ}C$, relative humidity of 40% and air velocity varying from 0.68 to 1.43 m/s. Experiments show that pressure drop for R410A and R407C were 17.8∼20.2％ and 5∼6.8％ lower than those of R22 respectively for the degree of subcooling of 5$^{circ}C$. For the mass fluxes of 200∼250 kg/$m^2$s, the deviation between the experimental and predicted values for the pressure drop was less than $pm$20％ for R22, R407C and R410A.