A combined optimal design problem is discussed taking a 3-D truss structure as a design object. We use descriptor forms for a controlled object and a generalized plant because the structural parameters appear naturally in these forms. We consider not only the minimum weight design problem for the structure, but also the suppression problem of the effect of disturbances for the control system as the purpose of the design. A numerical example shows the validity of combined optimal design of the structure and control systems. We also consider the validity of the sensor-actuator collocation for the control system design in this paper.