According to economic growth theory, location configuration of business enterprises engaged in specific industries has spatial affinity. In this research we defined industrial concentration index to measure industry agglomeration using the characteristics of dispersion parameter of negative binomial distribution, and used the industrial concentration index to examine aspect of spatial configuration change. We utilized Census on Basic Characteristics of Establishments of 1995 and 2000 to deduce industrral concentration indices of 7 knowledge-based industries and 9 strategy-based industries of Choongbuk Province and analyzed the aspect of spatial configuration change.