Cooling the electronic equipment is one of the major focal points of the design process and the key to successful product launch. The two-phase loop thermosyphone which is a good candidate among many available options was investigated fur cooling of the high power amplifiers. The system is composed of evaporator which contains 6 parallel cold plates, fan cooled condenser, gas-liquid separator, and interconnecting tubes. Experiments were performed for several refrigerant charging values, hs and as a experiment result, the optimum charging value fur this system was proposed. In order to optimize the system design, the operating cycle pressure and inlet/outlet temperatures of evaporator and condenser are measured and analyzed. The effect of the three parameters such as flow rate and temperature of condenser cooling air, and thermal load on the evaporator are investigated. The lower the operating pressure and the cycle temperatures are also better to prevent the leakage of the system. The system invesigated in this paper can be directly used for cooling of a real unmanned wireless communication station.