To investigate the influence of the rock mass inhomogeneity caused by layer geometry on the regional stress distribution the cuboid models considering a homogenous rock mass, inhomogeneous rock mass with plane layers and with uneven layers were analyzed and discussed. It was confirmed that the structure and existence of layers in rock mass affected the regional stress distribution. An approach based on an inverse analysis of the measured local stresses and the 3D finite element analysis was suggested, and used to estimate the regional stress field of the homogeneous and inhomogeneous models, which consist of the surface geometry of ground and both the surface and layer geometry respectively. Additionally, the approach of the regional stress considering the layer geometry in the rock mass was verified to estimate the regional stress field for a site.