- HIV 동역학과 최적 제어를 이용한 약물 치료에 관한 고찰
- ㆍ 저자명
- 허영희,고지현,김진영,남상원,심형보,정정주
- ㆍ 간행물명
- 제어·자동화·시스템공학 논문지
- ㆍ 권/호정보
- 2004년|10권 6호|pp.475-486 (12 pages)
- ㆍ 발행정보
- 제어로봇시스템학회
- ㆍ 파일정보
- 정기간행물| PDF텍스트
- ㆍ 주제분야
- 기타
The interaction of HIV and human immune system was studied in the perspective of dynamics. We summarized the recent researches on drug scheduling using optimal control theory for HIV treatment. The drug treatment to make immune system to work properly is investigated based on mathematical models including memory CTLp. In the simulation results, it was verified that stopping medication after a certain period of treatment can lead a patient to be cured naturally by one s immune system. Also, we summarized and categorized the advantages and disadvantages of each HIV drug scheduling method. In conclusion, model-based predictive control is more efficient for making decision of drug dose than other methods, when there exist uncertainties on model parameters or state variables.