This paper presents the enhancement of oxygen transfer efficiency using vibrating intravascular lung assist device (VIVLAD) for patients having chronic respiratory problems. The flow rate was controlled by the pump and monitored by a built-in flow meter. The vibration apparatus was composed of a piezo-actuator, a function generator, and a power amplifier. Gas flow rates of up to 6 L/min through the 120-cm-long hollow fibers have been achieved by exciting a piezo-actuator. The output PVDF sensor and FRF (frequency response function) were investigated by various frequency in VIVLAD. As a result, the maximum oxygen transfer rate was found to occur with maximum amplitude and the transfer of vibration to the hollow fiber membranes. It was excited by the frequency band of 35 Hz at various distilled water flow rates, and various module types.