Comparison of the cooling performance is provided between the desiccant cool-ing systems incorporating a direct evaporative cooler and a regenerative evaporative cooler, respectively. Cycle simulation is conducted, and the cooling capacity and COP are evaluated at various temperature and humidity conditions. The COP of the system with a regenerative evaporative cooler and the regeneration temperature of 6$0^{circ}C$ is evaluated 0.65 at the outdoor air condition of 35$^{circ}C$ and 40% RH. This value is found about 3.4 times larger than that of the system with a direct evaporative cooler. Furthermore, incorporating a regenerative evaporative cooler eliminates the need for deep dehumidification in a desiccant dehumidifier that is necessary to achieve low air temperature in the system with a direct evaporative cooler. Subsequently, the regenerative evaporative cooler enables the use of low temperature heat source to regenerate the dehumidifier permitting the desiccant cooling system more beneficial compared with other thermal driven air conditioners.