This study presents a genetic algorithm-based method fur optimizing control parameters in the pressure control of electro-hydraulic pump with variable displacement. Genetic algorithms are general-purpose optimization methods based on natural evolution and genetics and search the optimal control parameters maximizing a measure that evaluates the performance of a system. Four control gains of the PI-PD cascade controller for an electro-hydraulic pressure control system are optimized using a genetic algorithm in the experiment. Optimized gains are confirmed by inspecting the fitness distribution which represents system performance in gain spaces. It is shown that genetic algorithm is an efficient scheme in optimizing control parameters of the pressure control of electro-hydraulic pump with variable displacement.