Laser welding techniques have been characterised for various materials. In this paper, the laser weldability of STS304 stainless steel and Inconel 600 at dissimilar metal welds using a continuous wave Nd:YAG laser are experimentally investigated. Inconel 600 is being used in a steam generator tubing of pressurized water reactor(PWR) exposed to some corrosion. Stress corrosion cracking can occur on this material. An experimental study was conducted to determine effects of welding parameters, on eliminating or reducing the extent welding zone formation at dissimilar metal welds and to optimize those parameters that have the most influence parameters such as focus length, power, beam speed, shielding gas, and wave length of laser were tested.