The Spar platform with deep draft is characterized as effective structure in extreme wave condition, which has larger natural period than that of waves in sea. In this paper, the time domain simulation of motion responses of Spar with catenary mooring line is presented in irregular waves. The memory effect is modeled by added mass at infinite frequency and convolution integrals in terms of wave damping coefficients. The added mass, wave damping coefficients and wave exciting forces are obtained from three-dimensional panel method in the frequency domain. The motion equations are consisted of forces for inertia, memory effect, hydrostatic restoring, wave exciting and mooring line. The forces of mooring line are modeled as quasi-static catenary cable.