In this paper, a new fault detection and isolation algorithm fur inertial sensor system is proposed. To identify the inertial sensor fault, single antenna GPS receiver is used as an effective redundancy source. To use GPS receiver as redundancy for the inertial sensors, the algorithm to estimate the attitude and acceleration using single antenna GPS receiver is adopted. By using Doppler shift of carrier phase signal and kinetic characteristics of aircraft, attitude information of aircraft can be obtained at the coordinated flight condition. Based on this idea, fault diagnosis algorithm for inertial sensors using single antenna GPS based attitude is proposed. For more effective FDI, decision variables considering the aircraft maneuver are proposed. The effectiveness of the proposed algorithm is verified through the numerical simulations.