Interaction behaviors of high-speed compressible viscous flow and thermal-structural response of structure are presented. The compressible viscous laminar flow behavior based on the Navier-Stokes equations is predicted by using an adaptive cell-centered finite-element method. The energy equation and the quasi-static structural equations for aerodynamically heated structures are solved by applying the Galerkin finite-element method. The finite-element formulation and computational procedure are described. The performance of the combined method is evaluated by solving Mach 4 flow past a flat plate and comparing with the solution from the finite different method. To demonstrate their interaction, the high-speed flow, structural heat transfer, and deformation phenomena are studied by applying the present method to Mach 10 flow past a flat plate.