The objectives of this experiment were to study the growth and development of fruiting body of the two Ganoderma lucidum isolates on log of the soft wood Paraserianthes falcataria and the hard wood Shorea sp., and determination of organic germanium and crude ganoderic acid content of the fruiting body produced. The two Ganoderma lucidum isolates used were one Indonesian native (Indonesia isolate) and another isolate was purchased from Fungi Perfecti, USA (commercial isolate). The development and quality of the primordium and fruiting body of the mushroom, in general, were influenced by the isolates used. The types of wood, however, had no effect on the quality of the primordium and fruiting body produced. The Indonesian isolate produced better fruiting body compared to that of the commercial isolate. The development of fruiting body from primordium, however, was low for the two isolates tested. In general, only about one third of the primordium developed further into mature fruiting bodies, except for the commercial isolate grown on the soft wood medium in which more than 60% of the primordium developed into mature fruiting body. Apart from producing normal fruiting body, the commercial isolate also produced an abnormal one, which had a white mature pileus, whereas the normal one was brownish red. The organic germanium concentration of the fruiting body produced on the hard wood, in general, was higher than that of grown on the soft wood. The fruiting body from commercial isolate had higher organic germanium concentration compared to that of Indonesian isolate in both wood types. The two isolates used, however, had almost the same value of the crude ganoderic acid concentration in both types of wood tested. The Indonesian isolate had higher total yield of both organic germanium and crude ganoderic acid of the fruiting body produced compared to that of the commercial isolate.