Nowadays the information exchange based on XML such as B2B electronic commerce is spreading. Therefore a systematic and stable management mechanism for storing the exchanged information is needed. For this goal there are many research activities for centering on relational databases the connection between XML application and databases. But when XML data which has hierarchical structure is stored as relational databases which are expressed as relational information, a set of 2-dimensional table, there is a limitation essentially. Accordingly the modeling methodology for storing such structured information in the form of object-relational databases is needed. In order to build good quality application systems, modeling is an important first step. In 1997, the OMG adopted the UML as its standard modeling language. Since industry has warmly embraced UML, its popularity should become more important in the future. So a design methodology based on UML is needed to develop efficient XML applications. In this paper, we propose a unified design methodology for XML applications based on object-relational database using UML. To reach these goals, first we propose a systematic three step methodology to extract UML, second we introduce a XML modeling methodology to design W3C XML schema using UML and third we propose a data modeling methodology for object-relational database schema to store exchanging XML data efficiently.