The two main purposes of this paper are to 1) investigate critical components of university information systems for information resources management, 2) develop a comprehensive framework model of university information systems for e-Business Era. Through a literature review and by employing group decision making techniques with managers of K University, critical components for developing university information systems were identified. The critical components of university information systems are 1) academic affaires. 2) general administration. (3) research administration. (4) information services. (5) management support, (6) cyber education. (7) knowledge management, (8) e-library. (9) mobile service. and (10) IT infrastructures. In the second stage. by employing IT experts in K University and other institutes. a comprehensive framework of university information systems for e-Business era was developed. The comprehensive framework shows that major components for university information resources management are (1) information infrastructure. (2) common operating environments. (3) applications/information services. The results of this study expect to help managers. who are in charge of university information systems. plan to develop information systems based on the framework proposed in this paper.