The purpose of this study was examine the relationship between smoking, general characteristics, and serum lipids in the normal adult. The subjects consist of 6,800 persons (male ; 4,309(63.4%), female ; 2,491(36.6%)) in A hospital in Kyungki-Do. The collected data were analyzed using T-test, and Multiple Regression by SPSS/WIN program. The result were following ; 1. Cigarette smoking was associated with decreased serum HDL cholesterol level (p<.001). 2. Serum LDL cholesterol level was not statistically correlated with smoking tend to level by 5.77mg/dl respectively. 3. Cigarette smoking was associated with elevated serum Triglyceride level (p<.001). 4. By using regression, HDL cholesterol level was negatively correlated with obesity and alcohol.. HDL cholesterol level was positively correlated with exercise. LDL cholesterol level was positively correlated with diet and obesity.　Triglyceride level was positively correlated with obesity and　alcohol. In conclusion, Smoking was the most correlated with Triglyceride among the serum lipid and Serum lipid was the most correlated with obesity. Thus, it is necessary to quit smoke and weight control for prevention from disease such as coronary heart disease and lung cancer.