Two new nickel vanadium borophosphate cluster compounds, $(NH_4)_{10}[Ni(H_2O)_5]_4[V_2P_2BO_{12}]_6{cdot}nH_2O$ (1) and $(NH_4)_{3.5}(C_3H_{12}N_2)_{3.5}[Ni(H_2O)_6]_{1.25}{[Ni(H_2O)_5]_2[V_2P_2BO_{12}]_6{cdot}nH_2O$ (2) have been synthesized and structurally characterized. Inter-diffusion methods were employed to prepare the compounds. The cluster anion $[(NH_4);{supset};V_2P_2BO_{12}]_6$ is used as a building unit in the synthesis of new compounds containing $Ni(H_2O){^{2+}_5}$ in the presence of pyrazine and 1,3-diaminopropane. Compounds contain isolated cluster anions with general composition ${[Ni(H_2O)_5]_n[(NH_4);{supset};V_2P_2BO_{12}]_6}^{-(17-2n)}$ (n = 2, 4). Crystal data: $(NH_4)_{10}[Ni(H_2O)_5]_4[V_2P_2BO_{12}]_6{cdot}nH_2O$, monoclinic, space group C2/m (no. 12), a = 27.538(2) ${AA}$, b = 20.366(2) ${AA}$, c = 11.9614(9) ${AA}$, ${eta}$ = 112.131(1)$^{circ}$, Z = 8; $(NH_4)_{3.5}(C_3H_{12}N_2)_b[Ni(H_2O)_6]_{3.5}{[Ni(H_2O)_5]_2[V_2P_2BO_{12}]_6{cdot}nH_2O$, triclinic, space group P-1 (no. 2), a = 17.7668(9) ${AA}$, b = 17.881(1) ${AA}$, c = 20.668(1) ${AA}$, ${alpha}$ = 86.729(1)$^{circ}$, ${eta}$ 65.77(1)$^{circ}$, ${gamma}$ = 80.388(1)$^{circ}$, Z = 2.