Knowledge management has been increasingly recognized as important in business management context. Although knowledge management has been proposed as an enabler to reach competitive advantage, little research has considered applying knowledge to business decision-making activities, which may be the main task of enterprise management. The application of knowledge to decision-making has a more significant impact on organizational performance than mere knowledge management for operational level processing. For this purpose, the present study proposes a decision support loop based on the integration of knowledge by adopting a cognitive modeling approach. The proposed model is then discussed, in the real context of an application case.