Frame composed of concrete-filled steel tubular columns and I-shaped steel beam has been researched in order to development reasonable connection details. The present paper describes the results of an experimental program in four different connection details. The connection details considered include through-bolt between I-shaped steel beams and concrete-filled steel tubular columns and two details of welded connections. One of the welded connection details is stiffened by angles welded in the interior of the profile wall at the beam flange level. The specimens were tested in a cruciform loading arrangement with variable monotonic loading on the beams and constant compressive load on the column. For through-bolt details, the contribution of friction and bearing were investigated by embedding some of the bolts in the concrete. The results of the tests show that through-bolt connection details are very ductility and the bearing is not important to the behavior of these moment connections. The angles welded in the interior of the profile wall increase the strength and stiffness of the welded connection detail. In addition, the behavior curves of these connections are compared and some interesting conclusions are drawn. The results are summarized for the strength and stiffness of each connection.