The main objectives of this paper are to determine optimum cutting conditions using experimental design method to manufacture pedicle screws. Generally, titanium alloys are known as difficult-to cut materials. In the machining of titanium alloy, high cutting temperature and strong chemical affinity between the tool and the work material are generated because of Its low thermal conductivity and chemical reactivity. Such phenomenon cause increase of tool wear and deterioration of surface quality. Thus, in this paper, required experimental investigations are performed to evaluate the machinability of titanium materials With tungsten carbide tools Required simulation and experiments are performed, and the results are investigated.